NHS England (NHSE) are split into the following directorates/regions:
| Region/Directorate | Code |
| Chair & Chief Executives Office | 990-CCEO |
| Chief Delivery Officer | 990-CDO |
| Chief Finance Officer | 990-CFO |
| Chief Operating Officer | 990-COO |
| Commercial | 990-COM |
| East of England | 990-EOE |
| London | 990-LON |
| Medical | 990-MED |
| Midlands | 990-MID |
| New Hospital Programme | 990-NHP |
| North East & Yorkshire | 990-NEY |
| North West | 990-NW |
| Nursing | 990-NUR |
| South East | 990-SE |
| South West | 990-SW |
| Strategy | 990-STR |
| Vaccination & Screening | 990-V&S |
| Workforce Training and Education | 990-WTE |
Transformation directorate
The Transformation directorate are further split into sub-directorates:
| Sub-directorate | Code |
| Clinical Transformation and Digital Clinical Informatics | 990-TD-CTDCI |
| Cyber | 990-TD-CY |
| Analytics | 990-TD-D&A |
| Business Operations | |
| Data Access and Partnerships | |
| Data and Analytics | |
| Data Services | |
| NDRS | |
| Digital Enablement | 990-TD-DE |
| Digital Policy Unit | 990-TD-DPU |
| Improvement | 990-TD-IMP |
| Info Tech | 990-TD-IT |
| Innovation | 990-TD-INNO |
| Private Office | 990-TD-PO |
| Product and Platforms | 990-TD-P&P |
| Governance & Delivery | 990-TD-G&D |
| Tech Arch | 990-TD-TA |